Drugs that may cause erection problems

A wide range of medical illnesses and therapies may lead to problems with sexual desire and eroticism. such as Sildenafil Cenforce 100 and Tadalafil Vidalista 20 (the main ingredients in Viagra and Cialis), operate by widening your blood arteries, allowing more blood to reach your penis more quickly. Recent over-the-counter drugs that can be used are Generic Viagra, Tadalista 20, Vidalista 20, Sildenafil Cenforce 100, and Fildena 100.

Antihypertensives, antidepressants, antipsychotics, and antiandrogens are among the most often linked medicines.

It will be possible for the doctor to personalize therapies for the individual and his or her partner if the possibility for drug-induced sexual issues and their negative influence on treatment adherence are understood.

Good clinical care necessitates having an open dialogue with the patient regarding sexual function and offering treatment options. especially aerobic exercise may help men with erectile dysfunction get and stay healthy.

Introduction

Men’s and women’s sexual dysfunction is exacerbated by a number of different prescription medication types.

Patients who have sexual dysfunction as a side effect of their medication are more prone to become non-compliant. Antihypertensives and antipsychotics have been shown to have this effect. Drinking alcohol, using recreational substances like opiates and stimulants, and taking hallucinogens may all impair sexual function. While alcohol may reduce inhibitions, it also delays climax and ejaculation when used for a short period of time. In many cases, drug abusers claim to have better sex lives than their spouses, although this is not always the case. 6

It is possible to have three distinct stages of sexual function: sexual desire, arousal, and orgasm. Any of these stages might cause issues for both men and women. A person’s relationship is also impacted by conditions including low libido in males, anorexia, anorgasmia, and painful sex, as well as erectile dysfunction and erectile dysfunction in women.

Hypertension treatment options

Sexual dysfunction is linked to high blood pressure. Antihypertensives may also be a factor in the condition, resulting in poor adherence to prescribed medication.

According to a study conducted throughout the world, erectile dysfunction was found in 20% of males using beta-blockers for hypertension. Diuretics and centrally-acting alpha agonists (such as clonidine) have both been linked to decreased sexual desire and performance. Erectile dysfunction and gynecomastia are both linked to the angiotensin receptor blocker spironolactone.

Sexual pleasure (34 percent) and sexual desire (41 percent) have been reported to have decreased.

Short, randomized research found that alpha-adrenergic medications like clonidine and prazosin diminish both desire and arousal. In women with hypertension, valsartan, an angiotensin II receptor antagonist, was shown to boost sexual desire and fantasies compared to beta-blocker atenolol.

Drugs with euphoric effects

In addition to treating the patient medically, it is critical to address the patient’s psychosocial needs and understand the impact of mental health concerns on their relationships.

17 Sexual dysfunction may impact any stage of sexual engagement in as many as 70% of depressed people. According to research, 30–80% of females and 45–80% of males with schizophrenia have sexual dysfunction. 19 These people may not be able to discern between their disease’s impact on sexual function and the medication they are taking to treat it.

Antidepressants

Sexual problems are common side effects of several antidepressant medications. Drugs that impede serotonin reuptake and serotonin noradrenaline reuptake may reduce lubrication in the genital area. In 5–71% of patients, they also reduce or eliminate orgasm. To prevent premature ejaculation, this side effect is employed therapeutically. Taking tricyclic antidepressants reduces the desire for sex and the ability to have sex.

The effects of certain medications are dependent on the way they work. Nortriptyline has a greater impact on erectile dysfunction than clomipramine but has less influence on orgasm, as an example.

Sexual dysfunction has also been linked to the use of monoamine oxidase inhibitors. The dosages of moclobemide observed to boost sexual desire were judged subtherapeutic in that study.

Venlafaxine and mirtazapine, two more antidepressants, have varying detrimental effects on sexual function.

Antipsychotics

Sexual function may be affected more by certain antipsychotics than others.

However, there was just one Cochrane review on antipsychotic-induced sexual dysfunction, and it only included trials on males.

Erectile dysfunction, lower orgasmic quality, and decreased desire for sex are all common side effects for men who use antipsychotic medications. Anorgasmia and diminished desire are among the symptoms that women encounter. Vaginal atrophy and tightness may occur as a consequence of estrogen shortage in women with dyspareunia. Galactorrhea affects both men and women equally.

In a recent epidemiological study of schizophrenia, ziprasidone was shown to be favored over olanzapine in individuals with decreased sexual desire.

Dopamine receptor blockage is a common side effect of antipsychotics. Both sexes have hypogonadism and hyperprolactinemia as a result of this inhibition of the hypothalamic–pituitary–gonadal axis. Arousal and orgasm are reduced as a result of this. Secondary amenorrhea and ovarian dysfunction in women are also common side effects, as are reduced testosterone in men.

It’s possible that antipsychotics have an influence on additional neurotransmitter routes that aren’t well known, such as histamine blockage, noradrenergic blockade, and anticholinergic effects.

Prolactin levels may be ascribed to dopamine receptor antagonists if they are established before taking the medicine. Pituitary tumors, which may cause hyperprolactinemia in people on dopamine receptor antagonists, should be evaluated.

Antiepileptics

Antiepileptic medicine users often have sexual dysfunction.

Topiramate and gabapentin have been linked to decreased libido in women and orgasmic dysfunction in males.

Contraceptives

The level of free testosterone in the blood is decreased by oral contraceptives. Women’s desire may be reduced as a result, even though there is insufficient data to back this up. Clinical accounts of the effects of oral contraceptives are influenced by the social setting, including the relationship, and the fear of pregnancy and sexually transmissible illnesses.

It has been reported that as many as 15% of women who use the contraceptive drug depot medroxyprogesterone acetate may have side effects including weight gain, mood swings, vaginal shrinkage, and diminished libido.

Cancer treatments

When a person is diagnosed with cancer and undergoes treatment, it may have a substantial effect on their sex life. Prostate and breast cancer patients who use long-acting gonadotropin-releasing hormone agonists have hypogonadism, resulting in decreased sexual desire, erectile dysfunction (ED), as well as orgasmic dysfunction.

Treatment for lower urinary tract symptoms and BPH

Erectile dysfunction was seen in 72.2 percent of men with lower urinary tract symptoms and 37.7 percent of men with no lower urinary tract symptoms. Surgery and other treatments for the lower urinary tract may help alleviate symptoms, but they can also increase or induce erectile dysfunction and malfunction of the ejaculatory organs.

Prostatic hyperplasia treatment with doxazosin and other alpha-blockers has been found to be no worse than placebo in terms of sexual function. Tamsulosin, on the other hand, was found to be associated with a roughly 10% increase in ejaculatory impairment in men who were treated with the drug.

Male infertility is caused by a number of other medicines

Cyproterone acetate, cimetidine, digoxin, and spironolactone are all antiandrogens, which prevent the androgen receptor from being activated. Arousal and orgasm are affected, as well as sexual desire in both sexes.45

 Prednisone, a common steroid used in the treatment of many chronic inflammatory conditions, lowers sexual desire and produces erectile dysfunction as a side effect.

 Sirolimus and everolimus, two immunosuppressive medications often used in kidney transplantation, may decrease gonadal function and result in erectile dysfunction.

Anti-HIV drugs have been linked to sexual dysfunction, with over half of men using them experiencing erectile dysfunction. 48

 Other medicines, such as antihistamines, pseudoephedrine, opioids, and recreational drugs, may induce sexual dysfunction and should be taken into account while evaluating a patient’s condition.